GHK-Cu (Glycyl-L-histidyl-L-lysine copper complex) is a naturally occurring copper-binding tripeptide found in human plasma, saliva, and urine, with plasma concentrations declining significantly with age — from approximately 200 ng/mL at age 20 to 80 ng/mL at age 60. This age-related decline has made GHK-Cu a subject of intense research interest in skin biology, wound healing, and anti-aging science.

Research indicates this peptide-copper complex influences multiple cellular processes through modulation of gene expression, with studies identifying effects on over 4,000 human genes involved in tissue repair, inflammation, antioxidant responses, and cell proliferation. GHK-Cu demonstrates the ability to stimulate collagen and glycosaminoglycan synthesis in fibroblasts while promoting angiogenesis through VEGF pathway activation.

The copper component of GHK-Cu facilitates superoxide dismutase (SOD) activity, contributing to antioxidant effects and protection against oxidative stress. Pure Pharm Peptides' GHK-Cu is verified at 99.898% purity at 100mg/vial — the largest quantity in our cosmetic research lineup.

Research Applications:

• Collagen and elastin synthesis in dermal fibroblast studies
• Wound healing and tissue regeneration research
• Antioxidant pathway and SOD activity studies
• Skin aging and anti-aging biology research
• Angiogenesis and VEGF pathway investigations
• Gene expression modulation and epigenetic research

Key Specifications:

• Purity: 99.898% verified by Freedom Diagnostics testing
• Dosage: 100mg per vial
• Category: Recovery
• Storage: -20°C or colder (lyophilized)
• Stability: Up to 2 years when stored properly

Research Highlights:

• 99.898% purity verified by Freedom Diagnostics HPLC analysis
• 100mg/vial — largest quantity for extensive cosmetic research protocols
• Naturally occurring in human plasma — declines with age
• Modulates over 4,000 human genes in research studies
• Molecular weight: 742.3 Da | CAS: 130120-56-8 | PubChem CID: 133697840